| abstract |
The present invention relates to compounds of formula (I), or all tautomers, stereoisomers and polymorphs thereof, their pharmaceutically acceptable salts or solvates, those for disease therapy. Regarding combination and use: Wherein R 1 is C 2-8 alkyl; C 2-8 alkenyl;-(C 1-6 alkyl) -aryl;-(C 1-6 alkyl) -heteroaryl;-(C 1-6 alkyl ) -Carbocyclyl;-(C 1-6 alkyl) -heterocyclyl; -aryl; -heteroaryl; -carbocyclyl or -heterocyclyl; wherein the aryl group or heteroaryl group is C 1-4 alkyl, C 1 -4 fluoroalkyl, C 1-4 alkoxy, C 1-4 fluoroalkoxy, hydroxy, -SO 2 (C 1-4 alkyl), -SO 2 N (C 1-4 alkyl) (C 1-4 alkyl), Optionally substituted with one or more substituents selected from -SOC 1-4 alkyl, -SOC 3-6 cycloalkyl, -C (O) O (C 1-4 alkyl), benzyloxy and phenyl. Can do; And the carbocyclyl and heterocyclyl groups can be optionally substituted with one or more substituents selected from —C 1-4 alkyl, —C 1-4 alkoxy, hydroxyl, halogen and oxo; R 2 represents H; C 1-4 alkyl or halogen; R 3 represents H; C 1-4 alkyl or halogen; and R 4 represents H; C 1-4 alkyl or halogen. ). [Chemical 1] [Selection figure] None |