| abstract |
The present invention relates to substituted benzodiazepinone, benzooxaazepinone and benzothiazepinone compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are also useful for the treatment of other pathologies including CNS disorders such as anxiety, depression, epilepsy, manic depression and bipolar disorder. The invention also provides a pharmaceutical composition comprising a compound of the invention as a single agent or in combination with one or more therapeutically active compounds and a pharmaceutically acceptable carrier. The present invention further includes acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain and CNS disorders (including but not limited to epilepsy, manic depression, depression) comprising administering the compounds and pharmaceutical compositions of the present invention. Treatment methods, including anxiety and bipolar disorder). |