| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L15-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate |
2008-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2010-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2010520181-A |
| titleOfInvention |
Osteopontin for the prediction and treatment of cardiovascular disease |
| abstract |
Osteopontin for the prediction and treatment of cardiovascular disease. The present invention relates to the use of endothelial progenitor cells (EPC) and osteopontin for the treatment of cardiovascular disease or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of developing these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and genes encoding osteopontin. The inventors have shown that osteopontin deficiency plays a mechanistic role in diabetic EPC dysfunction and has identified a new therapeutic pathway that can be targeted in diabetic vascular disease. Similarly, the inventors have also shown the role of OPN in cardiovascular disease. |
| priorityDate |
2007-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |