| abstract |
Also described are dispersions of compounds of formula I and polymers, such as HPMCAS and / or PVP, and compositions comprising the dispersion, methods of making the dispersion, and methods of using the dispersion. In one embodiment, the invention provides a compound of formula I, preferably (2R, 4S) -quinoline-4-carboxylic acid [1- (3,5-bis-trifluoromethyl-benzoyl) -2- (4-chloro (Benzyl) -piperidin-4-yl] amide, or an active metabolite thereof, or (2R, 4S) -quinazoline-4-carboxylic acid [1- (3,5-bis-trifluoromethyl-benzoyl) -2- Features a solid dispersion containing (4-chlorobenzyl) -piperidin-4-yl] amide and HPMCAS. |