| abstract |
The present invention relates to methods of modulating immune function through targeting of CLIP molecules and gamma delta T cells. The results treat, inhibit or otherwise treat a number of diseases and conditions, such as autoimmune diseases, transplant and cell transplant rejection, cancer, bacterial infections, HIV infections, and AIDS It is a novel method for introducing a wide variety of new treatment plans, as well as diagnosing and introducing treatment plans to subjects. In one aspect, the present invention provides a method for treating disorders associated with proliferation, activation and / or effector function of γδ T cells, wherein the method comprises the growth of CLIP molecule expressing cells with an effective amount of γδ T cells. In contact with an inhibitor of activation and / or effector function to interfere with proliferation, activation and / or effector function of γδT cells by the CLIP molecule-expressing cell. |