| abstract |
The present invention relates to a compound of the general formula I wherein X 1 , X 2 , X 3 and X 4 are hydrogen or a halogen atom or C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, C 3 -C 7 - cycloalkyl -C 1 -C 3 - alkylene, C 1 -C 6 - fluoroalkyl, C 1 -C 6 - alkoxy, C 1 -C 6 - fluoro alkoxyl, cyano, C (O) NR 1 R 2 , nitro, NR 1 R 2 , C 1 -C 6 -thioalkyl, -S (O) -C 1 -C 6 -alkyl, -S (O) 2 -C 1 -C 6 -alkyl, SO 2 NR 1 R 2 , NR 3 COR 4 , NR 3 SO 2 R 5 or an aryl group (the aryl group is optionally substituted) is independently represented; W is a nitrogen atom at the 1, 2, 3 or 4 position. Condensation of Formula II bound to A cyclic group; A is a 5- to 7-membered heterocycle containing 1 to 3 heteroatoms selected from O, S and N; the carbon and / or nitrogen atoms of A are optionally substituted Y is an optionally substituted heteroaryl. ], The compound is in the form of an addition salt to a base or acid as well as in the form of a hydrate or solvate. The invention also relates to preparation methods and therapeutic applications. |