| abstract |
The present invention relates to a fast dissolving, high titer, substantially amorphous material comprising tacrolimus and a stabilizer matrix optionally comprising a polymer or non-polymeric surfactant, a polymer or non-polymeric monosaccharide, or both. Compositions and methods of making and using nanostructured aggregates for intrapulmonary delivery, the aggregates comprising a surface area of greater than 5 m 2 / g as measured by BET analysis, and aqueous crystal solubility in simulated lung fluid Compositions and methods that exhibit supersaturation for at least 0.5 hours when 11 to 15 times as much tacrolimus is added. |