abstract |
The present invention relates to transgenic animals and compositions and methods relating to the characterization of gene function. In particular, the present invention provides a transgenic mouse comprising a disruption in the PRO1105, PRO1279 or PRO1783 gene. By such in vivo testing and characterization, such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; ocular abnormalities; immunodeficiencies; oncological disorders; bone metabolic disorders or disorders; Enables the valuable identification and discovery of therapeutic agents and / or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with disruption of various genes |