| abstract |
The present invention provides compounds of formula I: Wherein the compound is an inhibitor of aldosterone synthase (CYP11B2), and / or 11 beta-hydroxylase (CYP11B1), and / or aromatase, and thus by aldosterone synthase, aromatase, or CYP11B1 It can be used to treat mediated disorders or diseases. Accordingly, the compounds of formula I are hypokalemia, hypertension, congestive heart failure, renal failure, especially chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, heart failure after myocardial infarction Can be used to treat coronary heart disease, increased collagen formation, fibrosis and remodeling after hypertension and endothelial dysfunction. Finally, the present invention also provides a pharmaceutical composition. |