| abstract |
The present invention relates to 5,6,7,8-tetrahydro-imidazo [1,5-A] pyrazine derivatives of formula (I), [Chemical 1] Wherein X represents CH 2 or O; R 1 represents a phenyl group independently substituted by 1 , 2 or 3 substituents, the substituents being (C 1-4 ) alkyl, (C 1-4 ) independently selected from the group consisting of alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R 2 is (C 1-4 ) alkyl, (C 1-4 ) alkoxy, (C 2-4 ) represents alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C (O) NR 5 R 6 or cyclopropyl; R 3 represents (C 1-4 ) alkyl, (C 1-4 ) alkoxy - methyl or halogen; R 4 represents a (C 1-4) alkyl; R 5 represents hydrogen or (C 1-4) alkyl; R 6 is hydrogen or (C 1-4) alkyl Represents. The invention also relates to the pharmaceutically acceptable salts of such compounds; the use of such compounds as medicaments, in particular as orexin receptor antagonists. [Selection figure] None |