| abstract |
The present invention relates to general formula (I) [Chemical 1] Aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity, pharmaceutically acceptable acid or base addition salts thereof, N-oxides thereof With respect to the form or its quaternary ammonium salt, here the variables are defined in claim 1. It further relates to their manufacture, compositions comprising them and their use as medicaments. The compounds of the present invention include mental disorders such as, but not limited to, mood disorders such as anxiety, eating disorders, bipolar disorder and depression, psychosis such as schizophrenia, and sleep disorders; Useful for the prevention and / or treatment of obesity; diabetes; sexual disorders and neurological disorders. [Selection figure] None |