http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010511394-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P23-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
filingDate | 2007-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2010-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2010511394-A |
titleOfInvention | Method for enantioselective enzymatic reduction of secodione derivatives |
abstract | The present invention relates to a method for enantioselective enzymatic reduction of a secodione derivative of general formula I, [Chemical 6] In general formula I, the ring structure contains or does not contain one or several heteroatoms, R 1 is hydrogen or a C 1 -C 4 alkyl group, R 2 is hydrogen, a C 1 -C 8 alkyl group, or a protecting group for OH known in the prior art such as for example an ester, R 3 is hydrogen, methyl group, or halogen; Structural element [Chemical 7] Represents a benzene ring or a C 6 ring having 0, 1 or 2 C—C double bonds, Double bonds are optionally included at the 6/7 or 7/8 positions, and the carbons at the 1, 2, 4, 5, 6, 7, 8, 9, 11, 12, and 16 positions are hydrogen, Substituted with a C 1 -C 4 alkyl group, a halogen, or a phenyl group, the secodione derivative is reduced using oxidoreductase / dehydrogenase in the presence of NADH or NADPH as a cofactor. According to the invention, the secodione derivative is used in the reaction batch at a concentration of ≧ 10 g / l, and the oxidized cofactor NAD or NADP formed by the oxidoreductase / dehydrogenase is continuously regenerated. The |
priorityDate | 2006-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 468.