| abstract |
The present invention relates to 3- (3-amino-2- (R) -hydroxy-propyl) -1- (4-fluoro-phenyl) -8- (8-methyl-naphthalen-1-ylmethyl) -1,3,8 -Triaza-spiro [4.5] decan-4-one salts, pharmaceutical compositions containing them, and treatment of disorders and conditions modulated by their NOPs such as depression, anxiety, alcohol abuse, etc. Intended for use in The present invention further provides 3- (3-amino-2- (R) -hydroxy-propyl) -1- (4-fluoro-phenyl) -8- (8-methyl-naphthalen-1-ylmethyl) -1,3. It is directed to the preparation method (s) of 8-triaza-spiro [4.5] decan-4-one and its corresponding salt. [Selection figure] None |