abstract |
The azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) compared to other known stearoyl-coenzyme A desaturases. The compounds of the present invention may be used to treat cardiovascular diseases such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; Useful for prevention and treatment. [Chemical 1] |