| abstract |
The present invention relates to a synthetic peptide amide ligand of a kappa opioid receptor, and more particularly to an agonist of a kappa opioid receptor with little inhibition of P 450 CYP and little penetration into the brain. The synthetic peptide amide of the present invention has the following structure: Matches. Pharmaceutical compositions containing these compounds are useful in preventing and treating pain and inflammation associated with a wide variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain, and hyperalgesia. Other functional disorders and symptoms such as inflammation, eye and ear inflammation or pruritus, edema, hyponatremia, hypokalemia, intestinal obstruction, cough, glaucoma associated with symptoms such as IBD and IBS It can be treated or prevented with the pharmaceutical composition. |