| abstract |
The present invention relates to a purine or pyrimidine phosphonate compound of formula I or a pharmaceutically acceptable salt thereof, wherein B, X and R 1 to R 3 are as defined in the class and subclass in the specification. . These compounds can be used as antiviral drug precursors. The invention also relates to pharmaceutical compositions comprising these compounds and their use for the preparation of medicaments for treating and / or preventing viral infections in patients. The present invention also provides a method for producing these compounds. In particular, the present invention provides an H-phosphinate precursor intermediate of formula II, wherein B is a purine or pyrimidine base as defined herein, R 1 is a hydrogen atom, as well as methyl, ethyl , Hydroxymethyl, hydroxyethyl, and a C 1-6 haloalkyl group. |