| abstract |
The present invention provides polypeptides, nucleic acids and other compositions. Polypeptides, nucleic acids and other compositions are useful in treatment and diagnostic methods. One treatment method includes inhibiting the growth or proliferation of hyperproliferative cells, or inducing regression of hyperproliferative cells such as cells with a cell hyperproliferative disorder or reducing the level of LDL or oxLDL. In one embodiment, an isolated purified glycoprotein designated as SAM-6 receptor (SAM-6 / R), ie, SAM-6 / R glycoprotein is provided. In one embodiment, the SAM-6 / R glycoprotein has an apparent molecular weight in the range of about 80-82 kilodaltons (kDa) as determined by denaturing gel electrophoresis, at least one nitrogen (N) or different from Grp78 or An antibody having an oxygen (O) -linked carbohydrate moiety and designated as SAM-6 specifically binds to the SAM-6 / R glycoprotein. |