| abstract |
The present invention provides a compound represented by formula (I) wherein W 1 , W 2 , W 3 , W 4 , W 5 , B, X 1 , X 2 , X 3 , X 4 , X 5 , E, and L are As defined in the specification]. The compounds according to the invention are γ-aminolactoic acid receptor subtype B (GABA B ) positive allosteric modulators (enhancers), the compounds being used for the treatment of diseases or disorders such as anxiety, depression, epilepsy, integration Ataxia, cognitive impairment, contracture and stiff skeletal muscle, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving for cocaine and nicotine, panic disorder, trauma It is useful for providing a method for treating post-stress syndrome, excitatory urinary incontinence, gastroesophageal reflux disease, transient lower esophageal sphincter relaxation, functional gastrointestinal disorders and irritable bowel syndrome. |