| abstract |
The present invention relates to compounds of formula (I), their combinations and use for the treatment of diseases. [Chemical 1] (In the formula, R 1, heteroaryl, - carbocyclyl - heteroaryl, - alkenyl heteroaryl or - alkyl heteroaryl; R 2 is amino, halogen, hydroxyl, - alkoxy, - thioalkyl, -C (O) Alkyl optionally substituted with one or more groups selected from O-alkyl and —C (O) OH; alkyl, haloalkyl, amino, halogen, hydroxyl, alkoxy-, -thioalkyl, —C (O) O— Carbocyclyl optionally substituted by one or more groups selected from alkyl and —C (O) OH; alkenyl; alkynyl; -alkyl-aryl; -alkyl-heteroaryl; -alkyl-heterocyclyl; -alkyl-carbocyclyl -Aryl-heteroaryl; -heteroaryl-aryl; -heteroaryl-heteroaryl; -aryl-aryl; Le (monocyclic or bicyclic); heteroaryl (monocyclic or bicyclic); represents heterocyclyl; or R 2 may form a carbocyclyl group which is optionally substituted by one or more alkyl groups with R 4 R 3 is alkyl optionally substituted by one or more groups selected from amino, halogen, hydroxyl, alkoxy-, -thioalkyl, -C (O) OH and -C (O) O-alkyl; A carbocyclyl optionally substituted by one or more groups selected from alkyl, amino, halogen, haloalkyl, hydroxyl, -alkoxy, -thioalkyl, -C (O) OH and -C (O) O-alkyl; alkenyl; -Alkyl-aryl; -alkyl (aryl) 2 , -alkyl (heteroaryl) 2 , -alkyl (aryl) (heteroaryl), -alkyl-heteroaryl; heterocyclyl groups are alkyl, hydroxy -Alkyl-heterocyclyl; -alkyl-carbocyclyl; -aryl-heteroaryl; -heteroaryl-aryl; -aryl-aryl; -aryl-O- which may be optionally substituted by one or more groups selected from sil and oxo -Aryl-heteroaryl; -aryl-heteroaryl; -aryl-alkyl-aryl; -aryl-O-alkyl-aryl; -alkyl-C (O) -NH-alkyl-aryl; -alkyl- C (O) -NH-alkyl-heteroaryl; -alkyl-C (O) -NH-alkyl-heterocyclyl; piperidinyl or pyrrolidinyl can be optionally fused to optionally substituted phenyl, -alkyl-C (O )-(N-piperidinyl) or -alkyl-C (O)-(N-pyrrolidinyl); R 4 represents H or alkyl. ). [Selection figure] None |