| abstract |
The present invention relates to compounds of formula (I), their combinations and uses for disease therapy: [Chemical 1] (In the formula, R 1, heteroaryl, - carbocyclyl - heteroaryl, - alkenyl heteroaryl or - alkyl heteroaryl; R 2 is hydrogen, halogen, alkenyl; alkynyl; - alkenyl aryl; - alkenyl heteroaryl; Alkyl, halogen, hydroxyl, optionally substituted with one or more groups selected from halogen, hydroxyl, alkoxy-, -thioalkyl, -C (O) OH and -C (O) O-alkyl; A carbocyclyl optionally substituted with one or more groups selected from alkoxy-, -thioalkyl, -C (O) OH and -C (O) O-alkyl; -alkylcarbocyclyl; -alkylheterocyclyl; aryl; heteroaryl; heterocyclyl; - alkyl aryl; - alkyl (aryl) 2, - alkylheteroaryl; - aryl - Heteroaryl; heterocyclyl - aryl -; - aryl - aryl; - heteroaryl - aryl; - heteroaryl - represents heteroaryl, and -C a (O) R 4; R 3 is halogen; halogen, hydroxyl, alkoxy, thioalkyl, Alkyl; aryl; heteroaryl; represents —C (O) R 5 ; optionally substituted with one or more groups selected from —C (O) OH and —C (O) O-alkyl; R 4 And R 5 independently represents alkyl, aryl, heteroaryl, -alkylaryl, -alkylheteroaryl, carbocyclyl, heterocyclyl, -alkylcarbocyclyl and -alkylheterocyclyl; provided that R 1 is imidazolyl, -carbocyclyl- In the case of imidazolyl, -alkenyl-imidazolyl or -alkyl-imidazolyl, provided that R 3 is not —C (O) R 5 ). [Selection figure] None |