http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010508041-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-78 |
| filingDate | 2007-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2010508041-A |
| titleOfInvention | Identification of bitter taste ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| abstract | PROBLEM TO BE SOLVED: There is a need to identify specific ligands that activate human bitter T2R taste receptors, despite the understanding of T2R members controlling bitter taste and their possible role in gastrointestinal function. A further understanding of the binding properties of different T2Rs, particularly human T2Rs, to further promote its use in selecting compounds that have the desired taste modulating properties, ie, block or inhibit the taste of specific bitter compounds Would be very beneficial. The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to specific bitter compounds. The invention also relates to the discovery of specific hT2R9 alleles and their heterologous activities in a functional assay with the same bitter ligand. The invention also relates to the use of these T2R receptors in assays to identify ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds can be used and / or removed from additives in foods, beverages, cosmetics and pharmaceuticals to modify (block) T2R-related bitterness. T2R ligands also treat and modulate T2R-related gastrointestinal and metabolic functions and to treat gastrointestinal and metabolic diseases such as eating disorders, food sensitivity, food absorption, obesity, diabetes, Crohn's disease, celiac disease, and the like. It can be used as a therapeutic agent. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012121869-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014501787-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759441-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011136930-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10603291-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10610500-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013063049-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013528661-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11065215-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017163984-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7321493-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020120624-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012120513-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016523512-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10668031-B2 |
| priorityDate | 2006-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 718.