| abstract |
Two-thirds of an estimated 1.3 million newly diagnosed cancers in the United States ultimately receive several forms of radiation therapy as part of their treatment regimen. Radiation therapy is considered one of the most important and powerful treatments for many cancers, particularly localized cancers that have not metastasized. Of the tumors treated with radiation therapy, only a few (including lymphomas and seminoma) are highly responsive. Many other solid tumors (such as melanoma, glioblastoma, and prostate cancer) are typically very resistant to irradiation and tend to progress even after high doses of irradiation. The present invention relates to a novel radiosensitizer, its production method and use. Provided herein are compositions and methods for use in sensitizing cancer cells to radiation and chemotherapy. |