| abstract |
The present invention relates to pharmaceuticals for increasing protein expression and for use in the treatment of tumor and cancer diseases, heart and cardiovascular diseases, infections, autoimmune diseases or single gene diseases, for example in gene therapy Provided are base-modified RNA and uses thereof for the preparation of compositions, particularly vaccines. In addition, the present invention provides in vitro transcription methods, in vitro methods for increasing protein expression using base-modified RNA, and in vivo methods. |