| abstract |
The present invention relates to a compound of formula (I) Wherein Het is optionally substituted with a monocyclic or bicyclic heterocycle containing 1 to 4 heteroatoms selected from N, O or S, and R1 is X- ( AB) n-CONH2, X- (AB) n-O-CONH2, X- (AB) n-NH-CONH2, X- (CH2) m-heterocycloalkyl, X- (CH2) m-aryl and X- (CH2) m-heteroaryl, where X is -O-C (O), -NH-C (O), NH-CS, -NH-CO-CH2-O-; NH—CO—CH 2 —S—CH 2 —CO—NH—; —NH—CO— (CH 2) 2 —SO 2 —; —NH—CO—CH 2 —N (CH 3) —CO—, wherein A and B are Represents a simple bond, CH2, CH-alkyl, CH-aralkyl, n = 1, 2 and m = 0, 1 R 2 and R ′ 2 are H, halogen, CF 3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, free or alkyl group, carboxamide group, CO—NH Represents carboxy esterified by (alkyl) and NH—CO-alkyl groups, p = 1 to 4 and p ′ = 1 to 3, and L is a simple bond, CH 2, C (O), O, Represents S or NH, wherein all said groups are optionally substituted]. The present invention also relates to all isomers of the product and its salts used as pharmaceuticals. |