| abstract |
The present invention relates to peptides of general formula (I): R 1 -AA-R 2 that can control neuronal exocytosis, their stereoisomers, their racemic or non-racemic mixtures and cosmetically or pharmaceutically acceptable. Its salt. Wherein AA is a 3-40 contiguous amino acid sequence contained in the amino acid sequence of the SNAP-25 protein, R 1 is selected from the group consisting of H, an alkyl group, an aryl group, an aralkyl group and an acyl group; R 2 is selected from the group consisting of an amino group substituted or unsubstituted with an aliphatic group or a cyclic group, a hydroxyl group, and a thiol group, and when R 1 is H or an acetyl group, R 2 is substituted Not amino groups, hydroxyl groups and thiol groups. The present invention also relates to a method for producing the peptide, a cosmetic or pharmaceutical composition comprising it, and its use for treating a condition in need of neuronal exocytosis control, preferably for treating the skin. . |