abstract |
[Chemical 1] The present invention relates to novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apo B secretion / MTP inhibitory activity and concomitant lipid lowering activity. The present invention further provides a method for producing the compound, a pharmaceutical composition containing the compound, as well as atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, It also relates to use as a medicament for treating hyperlipidemia, diabetes and type 2 diabetes. Formula (I). |