| abstract |
The compounds of structural formula (I) are modulators of the androgen receptor (AR), which is a tissue selective manner. These compounds increase weak muscle tone, and symptoms caused by androgen deficiency or can be ameliorated by androgen administration, such as osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal Disease, fracture, bone damage after bone remodeling surgery, skeletal myopathy, frailty, skin aging, male sexual dysfunction, female postmenopausal syndrome, atherosclerosis, hypercholesterolemia, hyperlipidemia, Obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HFV exhaustion, prostate cancer, benign prostatic hypertrophy (BPH), abdominal fat accumulation, metabolic syndrome, type II diabetes, cancer cachexia , Alone or in treatment of Alzheimer's disease, muscular dystrophy, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune diseases Useful in combination with other active agents. |