| abstract |
5'-deoxy-5-fluoro-N-[(pentyloxy) -carbonyl] -cytidine (capecitabine) and crospovidone (particle size <) along with other pharmaceutically acceptable excipients that form fast disintegrating tablets 15-400 μm), at least one disintegrant selected from the group consisting of sodium croscarmellose, sodium starch glycolate, low substituted hydroxypropylcellulose, Pharmaburst C, or any combination thereof. A pharmaceutical composition is provided. The tablet disintegrates in water at 37 ° C. in less than 2 minutes, preferably less than 1 minute, in a USP disintegrator and has a hardness of 8-13 Strong Cobb units. |