| abstract |
Formula (I) [Chemical 1] A novel 5-substituted 7-amino [1,3] thiazolo [4,5, wherein R 1 , R 2 , R 3 , R 4 and n are as defined herein. -D] Pyrimidine derivatives, and pharmaceutically acceptable salts thereof, are described along with their methods of manufacture, pharmaceutical compositions containing them and their use in therapy. The compounds of formula (I) are CX 3 CR1 receptor antagonists and are therefore neurodegenerative disorders, demyelinating diseases, cardiovascular and cerebrovascular atherosclerotic disorders, peripheral vascular diseases, rheumatoid arthritis, lung diseases Particularly useful for the treatment or prevention of, for example, COPD, asthma or pain. |