| abstract |
The present invention relates to a compound of formula (I) [Chemical 1] Or at least 3,5-disubstituted pyrazolo [1,5-a] pyrimidines, wherein the symbols R 1 to R 4 are as defined herein, or a tautomer thereof or a N-oxide, or (preferably pharmaceutically acceptable) salt or hydrate or solvate thereof, and related embodiments. The compounds are themselves useful as protein kinase inhibitors and are therefore, for example, kinases of the PI3-kinase related protein kinase family, in particular lipid kinases and / or PI3 kinases (PI3K) and / or mTOR and / or DNA protein kinases And / or useful in the treatment of diseases that respond to inhibition of ATM and / or ATR and / or hSMG-1. |