| abstract |
Disclosed are urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods of preparing the compounds and compositions, and methods of treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH-mediated diseases, including hypertension diseases, cardiovascular diseases, inflammatory diseases and diseases associated with diabetes. The compositions of the invention comprise a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the invention. |