| abstract |
A compound of formula (I) for treating a condition or disease mediated by CCR2, or a condition or disease mediated by CCR9, wherein the disease or condition is atherosclerosis, restenosis, multiple sclerosis, inflammatory Intestinal disease, renal fibrosis, rheumatoid arthritis, obesity, diabetes, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, idiopathic pneumonia syndrome, pulmonary fibrosis, transplant rejection, graft-versus-host disease, cancer, and neuropathic pain And Ar is selected from the group consisting of substituted or unsubstituted C 6-10 aryl, and substituted or unsubstituted 5 to 10 membered heteroaryl. ; Y 1 Y 4 from, -CR 3a - -CR from 3d -, - N-, and -N + (O) - -, is selected from the group consisting of; wherein Y 1, Y 2, Y 3 , Or at least one of Y 4 is —N—. |