| abstract |
The present application relates to compounds of formula (I) that act as stimulators of soluble guanylate cyclase and the treatment of heart failure, angina pectoris, hypertension, pulmonary hypertension, ischemia, vascular disorders, thromboembolic disorders and arteriosclerosis And / or their use for prevention. L is phenyl, pyridyl, furyl, thienyl, thiazolyl, oxazolyl, isothiazolyl, isoxazolyl or (C 5 -C 7 ) -cycloalkyl, and M is the formula (a-1), (b-1) or (c -1) [Chemical 1] {Where, Bonded to the -CH2-L group, To the Q group, A, B, D and E are each CH, CR 1 or N, and no more than two ring members A, B, D and E are the same} A bicyclic heteroaryl group of And Q is, up to four, N, O and / or unsaturated or aromatic 5- or 6-membered heterocycle having a heteroatom S, L-CH 2 -M- Q (I). |