| abstract |
The present invention includes conformationally defined macrocycles that bind to and / or are functional modulators of the motilin receptor, including subtypes, isoforms, and / or variants thereof. A compound is provided. These macrocyclic compounds have, at a minimum, sufficient pharmacological properties that are useful as treatments for a range of disease symptoms. In particular, these compounds are found in diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea , C.I. difficile-related diarrhea, traveler diarrhea, graft-versus-host-induced diarrhea, diarrhea of other species, dyspepsia, irritable bowel syndrome, chemotherapy-induced nausea and vomiting (emesis) and postoperative nausea and vomiting, In addition to, but not limited to, functional gastrointestinal diseases, the present invention is useful for the treatment and prevention of diseases characterized by hypermotility and / or excessive gastrointestinal motility. In addition, the compounds have utility in the treatment of diseases and disorders characterized by reduced gastric or intestinal absorption such as short bowel syndrome, celiac disease, and cachexia. The compounds also have use in the treatment of inflammatory diseases and disorders of the gastrointestinal tract such as inflammatory bowel disease, ulcerative colitis, Crohn's disease, or pancreatitis. Accordingly, methods for treating such diseases and pharmaceutical compositions comprising the compounds of the present invention are also provided. |