| abstract |
The present invention is a modified hepatitis C virus (HCV) E2 glycoprotein comprising an HCV-E2 receptor binding domain (RBD) comprising an HVR1 variable region, an HVR2 variable region and an igVR variable region, wherein at least one of the variable regions In one embodiment, the modified HCV E2 glycoprotein is provided wherein at least a portion of the variable region is replaced with a mobile linker sequence. The present invention also provides vaccine compositions comprising the modified HCV E2 glycoprotein and methods of use thereof. |