| abstract |
The present invention is a method for diagnosing platelet function, (a) collecting a platelet-containing sample from the subject; and (b) preferably holding the sample under conditions capable of inhibiting plasma clotting and / or fibrin formation; (c) lysing a platelet function marker derived from the platelet or a variant of such marker; Wherein at least steps b) and c) are performed in a blood collection device and / or further the level of the platelet function marker in the solution is measured. Preferably, the platelet function marker is liquefied by activating platelets in vitro or by proteolysis. Suitable markers for platelet function include CD40L, sCD40L, P-selectin, soluble P-selectin, GP-IV, soluble GP-IV, GP-V, soluble GP-V, GP-VI, soluble GP-VI, CD63 Platelet factor 4 (PF-4), β-thromboglobulin (β-TG), or variants thereof. The methods of the present invention provide for the diagnosis or measurement of any platelet disease or hyperfunction, cardiovascular disease, and any disease associated with platelet or hyperfunction. [Selection] Figure 8 |