| abstract |
Disclosed are compositions and methods for modulating dendritic cell-T cell interactions. The present invention relates to the use of a compound that binds to a C-type lectin on the surface of dendritic cells in the preparation of a composition for modulating, in particular suppressing the immune response of an animal, in particular a human or other mammal. . The composition in particular modulates the interaction of dendritic cells and T cells, specifically C-type lectins on the surface of dendritic cells and ICAM on the surface of T cells. The composition is for immunotherapy, for immunosuppression, for the treatment of autoimmune diseases, for the treatment of allergies, and / or for the inhibition of HIV infection, to block / inhibit immune responses to specific antigens. Can be used for The compound that binds to the C-type lectin is preferably a mannose, fucose, plant lectin, antibiotic, sugar, protein, or antibody to the C-type lectin. The present invention also relates to such antibodies and to methods for isolating dendritic cells using such antibodies. [Selection figure] None |