| abstract |
Disclosed is a pharmaceutical formulation containing 3- (3-dimethylamino-1-ethyl-2-methyl-propyl) phenol in the form of a matrix for sustained release of an active substance. The matrix contains 1-80% by weight of one or more hydrophilic or hydrophobic polymers as a pharmaceutically acceptable matrix-forming agent and exhibits the following degradation rate within the test: 0.5 hours later , 3- (3-dimethylamino-1-ethyl-2-methyl-propyl) phenol is released in an amount of 3-35% by weight (based on 100% by weight of active substance), and after 1 hour, 5-50% by weight is released 2 hours later, 10-75% by weight was released, 3 hours later, 3- (3-dimethylamino-1-ethyl-2-methyl-propyl) phenol 15-82% by weight was released, and 6 hours later 30-97% by weight, after 12 hours, more than 50% by weight released, After 18 hours, more than 70% by weight is released, and after 24 hours, more than 80% by weight is released. [Selection] Figure 1 |