| abstract |
The present invention provides a novel crystalline polymorph of ritonavir and a method for preparing the same. In a powder X-ray diffraction pattern, the value of 2θ is 8.67 ° ± 0.1 °, 9.88 ° ± 0.1 °, 16.11 ° ± 0.1 °, 16.70 °. ± 0.1 °, 17.36 ° ± 0.1 °, 17.78 ° ± 0.1 °, 18.40 ° ± 0.1 °, 18.93 ° ± 0.1 °, 20.07 ° (2S, 3S, 5S) -5 with peaks at ± 0.1 °, 20.65 ° ± 0.1 °, 21.71 ° ± 0.1 ° and 25.38 ° ± 0.1 ° (N- (N-((N-methyl-N-((2-isopropyl-4-thiazolyl) methyl) amino) carbonyl) -L-valinyl) amino) -2- (N-((5-thiazolyl) methoxy Carbonyl) amino) -1,6-diphenyl-3-hydroxyhexane substantially pure crystalline polymorph. A method for preparing the crystalline polymorph comprising inoculating a solution of ritonavir with seed crystals and then adding an anti-solvent. [Selection figure] None |