| abstract |
Characterization and identification of CpG-R, to distinguish other proteins or receptors from CpG-R that can lead to similar immune responses. The present invention relates to nucleic acid molecules and polypeptides encoding a CpG receptor (CpG-R). This CpG-R contains THD, can interact with MyD88 adapter protein, and can bind to CpG oligonucleotides. The present invention relates to antibodies to CpG-R and methods for modulating immune responses and methods for identifying compounds that bind to and / or modulate CpG-R. The invention also relates to the use of a polypeptide as a CpG receptor, the polypeptide comprising a Toll homology domain and binding to a CpG oligonucleotide. [Selection figure] None |