| abstract |
Disclosed is an external preparation for skin that exhibits a preventive or therapeutic effect on dysfunction associated with aging or illness of the skin safely when applied to the skin. A topical skin preparation containing cryptoxanthin and / or a derivative thereof having an action of activating retinoic acid receptor (RAR) present in epidermis or dermal cells, and further promoting the proliferation of human skin fibroblasts and And / or a skin external preparation having an effect of promoting collagen production, and preferably cryptoxanthin and / or a derivative thereof is citrus, particularly Unshu mandarin. [Selection] Figure 1 |