| abstract |
Non-steroidal anti-inflammatory compounds that do not have the side effects associated with prior art compounds, as well as new and improved treatments for inflammatory disease states and disorders, and ophthalmic diseases and disorders. SOLUTION: A nitric oxide group (NO) and / or a nitrogen dioxide group (NO2) can be bonded to a non-steroidal anti-inflammatory compound, and the resulting compound has excellent bioavailability, an analgesic and an anti-inflammatory It is pharmacologically effective and has the potential to produce unexpectedly reduced gastrointestinal damage (ulcers). It also has unexpected properties in the treatment and / or prevention of ophthalmic diseases and disorders. That is, nitrosated and / or nitrosylated non-steroidal anti-inflammatory compounds treat, prevent and / or reduce inflammation, pain and fever and reduce gastrointestinal, renal or other toxicities through the use of non-steroidal anti-inflammatory drugs Or how to recover. [Selection figure] None |