| abstract |
Disclosed is a formulation for controlled and sustained release of biologically active molecules such as therapeutic proteins, peptides and oligonucleotides. Solid microparticles or nanoparticles formed from a combination of biodegradable synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof, which have physiological activity The molecules are conjugated to a hydrophilic polymer such as polyethylene glycol or polypropylene glycol and formulated for controlled release. The bioactive molecule is more stable, less immunogenic, has an excellent release rate curve, lower burst level and lower loading than the same bioactive molecule without hydrophilic polymer bound Many. The controlled release formulation can be administered by injection, inhalation, nostril, or orally. [Selection figure] None |