| abstract |
An MRI contrast agent excellent in blood stability, tissue directivity and tumor accumulation property is provided. An MRI contrast medium for tissue imaging comprising superparamagnetic iron oxide (SPIO) particles surface-modified with a copolymer of a sugar chain-containing monomer and an anionic monomer. Preferably, the terminal sugar chain of the sugar chain-containing monomer is at least one selected from the group consisting of galactose, glucose, mannose, fucose, acetylglucosamine, and acetylgalactosamine, and the anionic monomer is an amino acid having a carboxylic acid as a side chain. , At least one selected from the group consisting of monomers having malic acid, methacrylic acid, maleic acid, vinyl benzoic acid and acrylic acid. [Selection] Figure 1 |