| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caff4e52a86eede27489d60c82ddd876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fbcdb105756f552ddf2e9ae2cfcf40a |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79e888296b131e0736f30a3b92fa6b00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4104de6888f57d21028a0f8d9cf900b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3389ef08ef0ff93841aa3d7e8759dff3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ebc9f13322811f598264e1e3edd88ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_157e25d06d61d21cd85ed0a59b23bb91 |
| publicationDate |
2010-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2010207097-A |
| titleOfInvention |
Hearing loss model animal and its use |
| abstract |
An object of the present invention is to provide a model animal exhibiting a deafness phenotype and its use in order to establish a means for preventing or treating hearing loss and tinnitus. A rodent genetically modified animal exhibiting an age-related deafness phenotype is provided by the impaired Ret gene of one allele. In addition, a method for screening a substance effective for the prevention or treatment of age-related hearing loss or noise-induced hearing loss using the rodent genetically modified animal is provided. On the other hand, rodent genetically modified animals exhibiting a congenital deafness phenotype are provided by the impaired Ret gene of both alleles. In addition, a method for screening a substance effective for treating congenital deafness using the rodent genetically modified animal is provided. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102178751-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014042262-A1 |
| priorityDate |
2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |