abstract |
The present invention provides an immunogenic composition comprising an adjuvant with significant immunostimulatory capacity, and in particular a composition comprising a phospholipid adjuvant. The present invention is an immunogenic composition containing a phospholipid adjuvant comprising microparticles and an emulsion composition. According to one feature of the present invention, water; a biodegradable polymer such as poly (α-hydroxy acid), polyhydroxybutyric acid, polycaprolactone, polyorthoester, polyanhydride and polycyanoacrylate is selected. A polymer microparticle comprising a polymer; an antigen adsorbed to the microparticle; and a phospholipid compound, such as (i) one or more phosphoryl groups independently selected from phosphate groups and phosphodiester groups; (ii) a plurality of linear alkane groups An immunogenic composition comprising a synthetic phospholipid compound comprising: [Selection figure] None |