| abstract |
Disclosed is a small molecule caspase and a TNF-α inhibitor that have potent, stable and good membrane penetration properties that effectively block apoptosis in vivo. The present invention relates to a new class of compounds of formula (I), which are caspases and inhibitors of TNF-α. The invention also relates to pharmaceutical compositions containing these compounds. The compounds and pharmaceutical compositions of the present invention are particularly suitable for inhibiting the activity of caspases and TNF-α, and consequently advantageously, caspases, interleukin-1 (“IL-1”) , Apoptosis, interferon-gamma-inducing factor (IGIF), interferon-gamma ("IFN-gamma") or TNF-alpha-mediated diseases (including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infections) Can be used as a drug against sexually and degenerative diseases). The invention also relates to a method for preparing the compounds of the invention. [Selection figure] None |