| abstract |
Aminomethyl-substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are provided. Tetracycline compounds of the formula: or pharmaceutically acceptable salts, prodrugs, and esters thereof. Wherein R1 and R2 combine to form a ring. R1 and R2 combine to form a 5-membered or 6-membered ring. In another, R1 and R2 combine to form 6 R1 and R2 form, for example,-(CH2) 5-6,-(CH2) 1-5-CH = CH- (CH2) 1-5-,-(CH2) 1-5-O- (CH2) 1-5-,-(CH2) 1-5-NR- (CH2) 1-5, etc. may be joined by a chain of atoms, etc. The ring formed may be saturated, For example, R1 and R2 may combine to form a piperidine ring, a morpholine ring, a pyridine ring, or a pyrazinyl ring. [Selection figure] None |