abstract |
The present invention provides genes encoding melanoma antigens recognized by T cells, proteins corresponding thereto, and methods for prevention, diagnosis and treatment using these genes or proteins. A nucleic acid sequence encoding a melanoma antigen named MART-1 recognized by T lymphocytes, a protein encoded by the nucleic acid sequence, and an antibody against the protein. A bioassay for diagnosing, evaluating or prognosing melanoma or metastatic melanoma using the antigen protein and the antibody. In addition, an immunogenic peptide derived from MART-1 and a second melanoma antigen designated gp100. An immunogenic peptide derived from MART-1 melanoma antigen or gp100 antigen and modified to enhance immunogenicity. Use of the proteins and peptides as immunogens for the prevention or treatment of melanoma. [Selection figure] None |