| abstract |
Provided is a protein having a nitrile hydratase activity, which is further improved in heat resistance and amide compound resistance by improving wild-type nitrile hydratase. The following protein (A) or (B): (A) A protein comprising an amino acid sequence in which a specific amino acid residue is substituted with another amino acid residue in the amino acid sequence of wild-type nitrile hydratase, and having a nitrile hydratase activity (B) The amino acid sequence of the protein (A) includes an amino acid sequence in which one or several amino acid residues are deleted, substituted and / or added except for the specific amino acid residue, and has a nitrile hydratase activity. Proteins characterized by having [selection figure] None |